Dutia M B, Gilchrist D P, Sansom A J, Smith P F, Darlington C L
Department of Physiology, University of Edinburgh Medical School, United Kingdom.
Exp Neurol. 1996 Sep;141(1):141-4. doi: 10.1006/exnr.1996.0147.
The opioid receptor antagonist, naloxone, has been demonstrated to enhance recovery from spinal cord injury and fluid percussion brain injury. The present study investigated, for the first time, the effects of naloxone on behavioral recovery following unilateral peripheral vestibular deafferentation (unilateral labyrinthectomy, UL) in guinea pig. An ip injection of 5 mg/kg naloxone 30 min pre-UL and 5 h post-UL was found to significantly reduce the frequency of spontaneous nystagmus relative to the vehicle control group (P < 0.005). However, a lower dose (2.5 mg/kg) had no effect. At either dose, the effects on the postural symptoms, yaw head tilt and roll head tilt, were small by comparison and in most cases nonsignificant. These results suggest that naloxone can reduce the ocular motor effects of UL in a dose-dependent fashion.
阿片受体拮抗剂纳洛酮已被证明可促进脊髓损伤和液压冲击性脑损伤后的恢复。本研究首次调查了纳洛酮对豚鼠单侧外周前庭去传入（单侧迷路切除术，UL）后行为恢复的影响。结果发现，在UL前30分钟和UL后5小时腹腔注射5mg/kg纳洛酮，与溶剂对照组相比，可显著降低自发性眼球震颤的频率（P<0.005）。然而，较低剂量（2.5mg/kg）则无此效果。与眼球震颤相比，两种剂量对姿势症状（偏航性头部倾斜和侧滚性头部倾斜）的影响较小，且在大多数情况下无统计学意义。这些结果表明，纳洛酮能够以剂量依赖性方式减轻UL对眼球运动的影响。
