Alice C, Paul A E, Sansom A J, Maclennan K, Darlington C L, Smith P F
Department of Pharmacology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand.
J Vestib Res. 1998 May-Jun;8(3):201-7.
Recent studies have suggested that steroids such as dexamethasone and methylprednisolone might be useful in the treatment of vestibular disorders, irrespective of whether inflammatory processes are involved. The aim of this study was to investigate the effects of systemic administration of dexamethasone on vestibular compensation of spontaneous nystagmus (SN) in guinea pig, and the effects of dexamethasone and methylprednisolone on extracellularly recorded spontaneous activity of medial vestibular nucleus (MVN) neurons in brainstem slices in vitro. In the behavioral study, none of the 3 doses of dexamethasone (5, 10, or 40 mg/kg i.p., delivered at 0, 12, 24, and 36 h following a unilateral surgical labyrinthectomy (UL)) resulted in a significant change in the frequency or compensation of SN, relative to the vehicle control group. In the in vitro study, only a minority of MVN neurons showed any response to 1 microM dexamethasone (1 out of 9 neurons), or 10 nM (3 out of 13), or 0.1 microM methylprednisolone (3 out of 7). These results suggest, contrary to previous evidence, that dexamethasone may not accelerate compensation of SN following surgical UL and that dexamethasone and methylprednisolone may have a direct action only on a minority of MVN neurons.
近期研究表明，地塞米松和甲泼尼龙等类固醇药物可能有助于治疗前庭疾病，无论是否涉及炎症过程。本研究的目的是调查全身给予地塞米松对豚鼠自发性眼球震颤（SN）前庭代偿的影响，以及地塞米松和甲泼尼龙对体外脑干切片中前庭内侧核（MVN）神经元细胞外记录的自发活动的影响。在行为学研究中，相对于溶剂对照组，3种剂量的地塞米松（5、10或40mg/kg腹腔注射，在单侧手术迷路切除（UL）后0、12、24和36小时给药）均未导致SN频率或代偿出现显著变化。在体外研究中，只有少数MVN神经元对1μM地塞米松（9个神经元中的1个）、10 nM（13个中的3个）或0.1μM甲泼尼龙（7个中的3个）有任何反应。这些结果表明，与先前的证据相反，地塞米松可能不会加速手术UL后SN的代偿，并且地塞米松和甲泼尼龙可能仅对少数MVN神经元有直接作用。
