Nimgaonkar V L, Zhang X R, Brar J S, DeLeo M, Ganguli R
Department of Human Genetics, University of Pittsburgh School of Medicine, PA, USA.
Psychiatr Genet. 1996 Spring;6(1):23-7.
In view of a reported association between schizophrenia and the 5-HT2 receptor gene locus, as well as an association with treatment refractoriness at this locus, a case-control association study was conducted using a biallelic polymorphism. The distribution of the polymorphism was investigated among patients with schizophrenia (DSM-III-R, n = 174) and unaffected controls (n = 239). No significant differences in genotype distributions or allele frequencies were noted between the two groups. In support of the earlier report, a significant excess of individuals homozygous for allele C2 was noted among patients who responded unsatisfactorily to antipsychotic medication in comparison with the controls (odds ratio 1.78; 95% confidence intervals 1.06, 2.97). However, this difference was not significant following multivariate analysis. This study does not support an association between the 5-HT2 receptor gene locus and schizophrenia or subgroups based on treatment response.
鉴于有报道称精神分裂症与5 - HT2受体基因位点之间存在关联，以及该位点与治疗难治性相关，因此利用双等位基因多态性进行了一项病例对照关联研究。在精神分裂症患者（DSM - III - R，n = 174）和未受影响的对照者（n = 239）中调查了该多态性的分布情况。两组之间在基因型分布或等位基因频率上未发现显著差异。与早期报告一致的是，与对照组相比，对抗精神病药物反应不佳的患者中，等位基因C2纯合的个体显著过多（优势比1.78；95%置信区间1.06, 2.97）。然而，多变量分析后该差异并不显著。本研究不支持5 - HT2受体基因位点与精神分裂症或基于治疗反应的亚组之间存在关联。
