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Processing and presentation of an antigen of Mycobacterium avium require access to an acidified compartment with active proteases.鸟分枝杆菌抗原的加工和提呈需要进入含有活性蛋白酶的酸化区室。
Infect Immun. 1996 Oct;64(10):4091-8. doi: 10.1128/iai.64.10.4091-4098.1996.
2
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis.在携带鸟分枝杆菌和结核分枝杆菌的巨噬细胞中，组织蛋白酶L的成熟和活性受损。
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Differential requirements for the processing and presentation of soluble and particulate bacterial antigens by macrophages.巨噬细胞对可溶性和颗粒性细菌抗原进行加工和呈递的不同要求。
Eur J Immunol. 1987 Sep;17(9):1287-96. doi: 10.1002/eji.1830170911.
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Bacterial antigen processing in macrophages infected with the obligate intracellular bacterium, Mycobacterium avium.感染专性胞内细菌鸟分枝杆菌的巨噬细胞中的细菌抗原加工。
Acta Leprol. 1989;7 Suppl 1:175-6.
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Bacterial antigen delivery systems: phagocytic processing of bacterial antigens for MHC-I and MHC-II presentation to T cells.细菌抗原递呈系统：细菌抗原的吞噬加工，用于MHC-I和MHC-II呈递给T细胞。
Behring Inst Mitt. 1997 Feb(98):197-211.
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Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation.结核分枝杆菌与 ATP 协同作用诱导含有主要组织相容性复合体 II 类分子的微囊泡和外泌体释放，这些分子能够进行抗原呈递。
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Trinitrophenol reactive T-cell hybridomas recognize antigens that require antigen processing.三硝基苯酚反应性T细胞杂交瘤识别需要抗原加工的抗原。
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Antigen presentation by macrophages from bacille Calmette-Guérin (BCG)-resistant and -susceptible mice.来自卡介苗（BCG）抗性和敏感性小鼠的巨噬细胞的抗原呈递。
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Production of a monoclonal antibody specific for Mycobacterium avium and immunological activity of the affinity-purified antigen.针对鸟分枝杆菌的单克隆抗体的制备及亲和纯化抗原的免疫活性
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Diet modulates colonic T cell responses by regulating the expression of a antigen.饮食通过调节 a 抗原的表达来调节结肠 T 细胞的反应。
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Growth within macrophages increases the efficiency of Mycobacterium avium in invading other macrophages by a complement receptor-independent pathway.巨噬细胞内的生长通过不依赖补体受体的途径提高了鸟分枝杆菌侵入其他巨噬细胞的效率。
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本文引用的文献

1
Intracellular fate of Mycobacterium avium: use of dual-label spectrofluorometry to investigate the influence of bacterial viability and opsonization on phagosomal pH and phagosome-lysosome interaction.鸟分枝杆菌的细胞内命运：利用双标记荧光光谱法研究细菌活力和调理作用对吞噬体pH值及吞噬体-溶酶体相互作用的影响。
Infect Immun. 1996 Jan;64(1):319-25. doi: 10.1128/iai.64.1.319-325.1996.
2
Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice.鸟分枝杆菌感染可诱导白细胞介素-10（IL-10）的产生，给小鼠注射抗IL-10抗体与增强其抗感染能力有关。
Infect Immun. 1993 Jul;61(7):3093-7. doi: 10.1128/iai.61.7.3093-3097.1993.
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Immunity to intracellular bacteria.对细胞内细菌的免疫
Annu Rev Immunol. 1993;11:129-63. doi: 10.1146/annurev.iy.11.040193.001021.
4
Production of transforming growth factor-beta by Mycobacterium avium-infected human macrophages is associated with unresponsiveness to IFN-gamma.鸟分枝杆菌感染的人类巨噬细胞产生转化生长因子-β与对γ干扰素无反应有关。
J Immunol. 1993 Mar 1;150(5):1838-45.
5
Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase.通过排除囊泡质子 - ATP酶导致吞噬体中缺乏酸化作用。
Science. 1994 Feb 4;263(5147):678-81. doi: 10.1126/science.8303277.
6
MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.主要组织相容性复合体（MHC）依赖性抗原加工与肽呈递：为T淋巴细胞激活提供配体
Cell. 1994 Jan 28;76(2):287-99. doi: 10.1016/0092-8674(94)90336-0.
7
Disseminated tuberculosis in interferon gamma gene-disrupted mice.干扰素γ基因敲除小鼠中的播散性结核病
J Exp Med. 1993 Dec 1;178(6):2243-7. doi: 10.1084/jem.178.6.2243.
8
Immunity to mycobacteria.对分枝杆菌的免疫
Curr Opin Immunol. 1993 Aug;5(4):497-502. doi: 10.1016/0952-7915(93)90029-r.
9
Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages.在人类巨噬细胞中生长的分枝杆菌与免疫CD4 + T细胞隔离。
Science. 1993 May 14;260(5110):984-6. doi: 10.1126/science.8098550.
10
Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.结核分枝杆菌和鸟分枝杆菌感染巨噬细胞中的细胞内运输
J Immunol. 1994 Sep 15;153(6):2568-78.

鸟分枝杆菌抗原的加工和提呈需要进入含有活性蛋白酶的酸化区室。

Processing and presentation of an antigen of Mycobacterium avium require access to an acidified compartment with active proteases.

作者信息

Holsti M A, Allen P M

机构信息

Center for Immunology and Department of Pathology, Washington University Medical Center, St. Louis, Missouri 63110, USA.

出版信息

Infect Immun. 1996 Oct;64(10):4091-8. doi: 10.1128/iai.64.10.4091-4098.1996.

DOI:10.1128/iai.64.10.4091-4098.1996
PMID:8926074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174342/
Abstract

We have generated a murine T-cell hybridoma, 1C9, which recognizes an antigen expressed by a virulent clinical isolate of Mycobacterium avium. Both peritoneal exudate macrophages and bone marrow-derived macrophages infected in vitro with M. avium process and present the antigen to the T-cell hybridoma. Gel filtration chromatography of a sonicate of M. avium followed by T-cell Western blotting (immunoblotting) demonstrated that the antigen recognized by hybridoma 1C9 is approximately 50 kDa. In addition, treatment of macrophages with the lysosomotropic agent chloroquine or with inhibitors of acid proteases inhibits processing and presentation of the antigen. These results indicate that the antigen must encounter an acidic compartment with active proteases for processing and presentation to occur. Our results are discussed in the context of our current understanding of how mycobacterial antigens are processed and presented by infected macrophages to T cells.

摘要

我们制备了一种小鼠T细胞杂交瘤1C9，它能识别由鸟分枝杆菌的一种强毒临床分离株表达的抗原。用鸟分枝杆菌体外感染的腹膜渗出巨噬细胞和骨髓来源的巨噬细胞都能处理该抗原并将其呈递给T细胞杂交瘤。对鸟分枝杆菌超声裂解物进行凝胶过滤层析，随后进行T细胞免疫印迹分析（免疫印迹法），结果表明杂交瘤1C9识别的抗原约为50 kDa。此外，用溶酶体促渗剂氯喹或酸性蛋白酶抑制剂处理巨噬细胞会抑制该抗原的处理和呈递。这些结果表明，该抗原必须进入含有活性蛋白酶的酸性区室才能进行处理和呈递。我们将结合目前对感染巨噬细胞如何处理分枝杆菌抗原并将其呈递给T细胞的理解来讨论我们的结果。