Jagielski P, Nitkiewicz J, Swiderska H, Kalinowska B
Zakład Immunopatologii PZH w Warszawie.
Med Dosw Mikrobiol. 1996;48(1-2):79-85.
Anti-idiotypic antibodies (anti-Id Ab) against antibodies to HBs, pre-S1 and pre-S2 antigenic domains of the HBV surface protein were searched for by enzyme-linked immunosorbent assay in single serum samples of 57 patients, chronic HBsAg carriers. IgG and/or IgM anti-Id Ab were detected in 15 patients (26%). IgG and / or IgM anti-[anti-HBs] anti-Id Ab were found in 8 serum samples (14%) and they appeared to occur more frequently in patients seropositive for HBeAg than in these seropositive for anti-HBe. IgG and / or IgM anti-[pre-S1] anti-Id Ab and IgG and / or IgM anti-[anti-pre-S2] anti-Id Ab were detected in 5 (9%) and 8 (14%) patients, respectively. Both these anti-Id Ab were found more frequently in patients seropositive for anti-HBe than in patients seropositive for HBeAg. Anti-[anti-pre-S2] anti-Id Ab occurred more frequently in patients with sever liver damage than in these with near normal liver or established cirrhosis.
通过酶联免疫吸附试验在57例慢性乙肝表面抗原携带者患者的单份血清样本中寻找针对乙肝病毒表面蛋白的乙肝表面抗体、前S1和前S2抗原结构域抗体的抗独特型抗体（抗Id抗体）。在15例患者（26%）中检测到IgG和/或IgM抗Id抗体。在8份血清样本（14%）中发现了IgG和/或IgM抗[抗-HBs]抗Id抗体，且它们在HBeAg血清阳性患者中出现的频率似乎高于抗-HBe血清阳性患者。分别在5例（9%）和8例（14%）患者中检测到IgG和/或IgM抗[前S1]抗Id抗体以及IgG和/或IgM抗[抗前S2]抗Id抗体。这两种抗Id抗体在抗-HBe血清阳性患者中出现的频率均高于HBeAg血清阳性患者。抗[抗前S2]抗Id抗体在严重肝损伤患者中出现的频率高于肝脏接近正常或已确诊肝硬化的患者。
