[特应性疾病患儿受刺激外周血单个核细胞中可溶性CD23血清水平及白细胞介素-4浓度]

[Serum levels of sCD23 and IL-4 concentration in stimulated PBMC in children with atopic diseases].

作者信息

Boznański A, Machnicki M, Willak-Janz E

机构信息

Katedra Pediatrii i Klinika Alergologii oraz Kardiologii Dzieciecoj Akademii Medycznej we Wrocławiu.

出版信息

Pediatr Pol. 1996 Sep;71(9):753-7.

PMID:8927482

Abstract

In this study we estimated the correlation between IgE and sCD23 serum levels, and the concentration of IL-4 in PHA-stimulated PBMC cultures in children with atopic diseases. Children with atopic dermatitis showed a high degree of correlation between sCD23-IgE while in the control group no such relationship was found. We also found no relationship between IL-4 and sCD23 in children with atopic asthma, relationship at children with atopic dermatitis, and no relationship in healthy children. Looking for relationship between IL-4 in PHA-stimulated PBMC and IgE serum levels we discovered a weak negative correlation in children with atopic asthma, a highly positive correlation in children with atopic dermatitis and no relationship in the control group.

摘要

在本研究中，我们评估了特应性疾病患儿血清中IgE与sCD23水平之间的相关性，以及PHA刺激的PBMC培养物中IL-4的浓度。特应性皮炎患儿的sCD23与IgE之间存在高度相关性，而在对照组中未发现这种关系。我们还发现，特应性哮喘患儿、特应性皮炎患儿的IL-4与sCD23之间均无相关性，健康儿童中也不存在这种关系。在PHA刺激的PBMC中的IL-4与IgE血清水平之间寻找相关性时，我们发现特应性哮喘患儿存在弱负相关，特应性皮炎患儿存在高度正相关，而对照组中无相关性。