McDonald J C, Cherry N, McNamee R, Burgess G, Turner S
Department of Occupational & Environmental Medicine, National Heart & Lung Institute, London, England.
Scand J Work Environ Health. 1995;21 Suppl 2:63-5.
A cohort of 7020 male pottery workers born in 1916-1945 was identified from all employees in dust-exposed trades, subject to medical surveillance by the Benefits Agency Medical Service of the Department of Social Security in Stoke-on-Trent in the United Kingdom. All but 256 (3.6%) were traced, 1016 (15.0%) had died by 30 June 1992, and death certificates were obtained for 940 (92.5%) of the fatalities - 122 from respiratory cancer. After the exclusion of any recorded asbestos exposure, the proportional mortality ratio (PMR) for lung cancer was 1.22 when calculated against national rates (P < 0.02), but the PMR against local rates was 1.04. Logistic regression analyses based on 75 nested case-referent pairs for which the required information was available showed that lung cancer mortality was dominated by smoking and significantly affected by past asbestos exposure. However, for 47 pairs in which both the case and referent had a history of smoking, there was also significant evidence that the risk was related to duration of silica dust exposure in pottery work but not to radiological score.
从英国特伦特河畔斯托克市社会保障部福利机构医疗服务部门接受医学监测的所有从事接触粉尘行业的员工中，确定了一组7020名出生于1916年至1945年的男性陶工。除256人（3.6%）外，其余人员均被追踪到，到1992年6月30日，1016人（15.0%）已死亡，其中940人（92.5%）的死亡证明已获取——122人死于呼吸道癌症。在排除任何有记录的石棉接触史后，与全国死亡率相比，肺癌的比例死亡率（PMR）为1.22（P<0.02），但与当地死亡率相比，PMR为1.04。基于75对巢式病例对照研究对进行的逻辑回归分析显示，肺癌死亡率主要由吸烟决定，且受既往石棉接触史的显著影响。然而，对于47对病例和对照均有吸烟史的对子，也有显著证据表明风险与陶工工作中二氧化硅粉尘接触时长有关，而与放射学评分无关。
