Kemp R A, Lambert T J
Academic Department of Psychological Medicine, King's College Hospital, London, UK.
Schizophr Res. 1995 Dec;18(1):21-8. doi: 10.1016/0920-9964(95)00018-6.
A group of 29 patients with DSM-IIIR schizophrenia was studied during acute hospital admission to examine the relationship between changes in insight and positive and negative symptomatology in schizophrenia. On admission, insight scores were obtained using a modification of the SUMD (Amador et al., 1993), and of the degree of psychopathology using the PANSS (Kay et al., 1987). These measures were repeated prior to discharge between 3 and 6 weeks later. Insight improved significantly during the course of in-patient treatment. A relationship between psychopathology and insight level was evident at both assessments, though the pattern was different. Improvement in psychopathology correlated significantly with increased insight into past symptoms but not current illness. When treatment responders were examined there was a significant relationship only with negative symptom improvement and PANSS totals, but not with improvement in positive symptoms. The greater the trend towards negative symptom predominance, the less the tendency to improve in the awareness of current symptoms. This study suggests an inverse relationship with enduring negative symptoms.
一组29名患有DSM-IIIR精神分裂症的患者在急性住院期间接受了研究，以探讨精神分裂症患者洞察力变化与阳性和阴性症状学之间的关系。入院时，使用SUMD的修订版（Amador等人，1993年）获得洞察力评分，并使用PANSS（Kay等人，1987年）评估精神病理学程度。在3至6周后的出院前重复这些测量。住院治疗期间，洞察力有显著改善。在两次评估中，精神病理学与洞察力水平之间的关系都很明显，尽管模式不同。精神病理学的改善与对过去症状的洞察力增加显著相关，但与对当前疾病的洞察力无关。当检查治疗反应者时，仅与阴性症状改善和PANSS总分存在显著关系，与阳性症状改善无关。阴性症状占主导的趋势越大，对当前症状的认识改善的趋势就越小。这项研究表明与持久的阴性症状呈反比关系。
