Collin H B, Allansmith M R
Invest Ophthalmol Vis Sci. 1977 Sep;16(9):858-64.
The histopathological changes of vernal conjunctivitis comprise stromal infiltration by lymphocytes, plasma cells, and neutrophilic, eosinophilic, and basophilic leukocytes and epithelial invasion by mast cells and eosinophils. Blood vessels show swelling and death of endothelial cells and increased permeability with associated extravasation of erythrocytes and fibrin. The presence of basophils in ocular tissue has not been reported previously, and their occurrence in conjunction with the other pathological changes enables vernal conjunctivitis to be compared with, and classified as a manifestation of, delayed-type hypersensitivity of the cutaneous basophil type. Thus the mechanism is probably a mixture of both delayed and immediate immunological responses.
春季结膜炎的组织病理学变化包括淋巴细胞、浆细胞以及嗜中性、嗜酸性和嗜碱性白细胞的基质浸润，以及肥大细胞和嗜酸性粒细胞的上皮侵袭。血管显示内皮细胞肿胀和死亡，通透性增加，伴有红细胞和纤维蛋白外渗。眼部组织中嗜碱性粒细胞的存在此前尚未见报道，它们与其他病理变化同时出现，使得春季结膜炎能够与皮肤嗜碱性粒细胞型迟发型超敏反应进行比较并归类为其一种表现形式。因此，其机制可能是迟发性和速发性免疫反应的混合。
