Easty D L, Birkenshaw M, Merrett T, Merrett J, Entwhistle C, Amer B
Trans Ophthalmol Soc U K (1962). 1980 Apr;100(Pt 1):98-107.
A group of patients with vernal disease was investigated for serum IgE levels, specific antibody to external allergens in serum and tears, and the frequencies of the HL-A antigens. Biopsies taken from the conjunctiva were examined by means of light and electron microscopy for the presence of mast cells and other inflammatory cells. Serum IgE was elevated in 75 per cent of the patients, all of whom demonstrated positive prick tests to common allergens and specific antibody in their serum using the radio-allergosorbent test (RAST). Specific antibody was also demonstrated in tears using the same technique. The distribution of the HL-A antigens showed no difference in frequency when compared with controls. Conjunctival biopsies demonstrated numerous mast cells, the more superficial of which were degranulating in active disease. In control biopsy material, mast cells were densely packed with granules. The clinical manifestations in vernal disease together with the infiltration of the tarsal conjunctiva with many types of inflammatory cell, are possible caused by mediators which are known to be produced by degranulating mast cells when they are stimulated by allergens.
对一组春季疾病患者进行了血清IgE水平、血清和泪液中针对外部过敏原的特异性抗体以及HL - A抗原频率的调查。对取自结膜的活检组织进行光镜和电镜检查，以确定肥大细胞和其他炎症细胞的存在情况。75%的患者血清IgE升高，所有这些患者对常见过敏原的点刺试验均呈阳性，并且使用放射变应原吸附试验（RAST）在其血清中检测到特异性抗体。使用相同技术在泪液中也检测到了特异性抗体。与对照组相比，HL - A抗原的分布频率没有差异。结膜活检显示有大量肥大细胞，在活动性疾病中，较浅表的肥大细胞正在脱颗粒。在对照活检材料中，肥大细胞充满了密集的颗粒。春季疾病的临床表现以及睑结膜被多种炎症细胞浸润，可能是由已知在过敏原刺激下脱颗粒的肥大细胞产生的介质引起的。
