Olusi S O, Fido A A
Department of Pathology, Faculty of Medicine, University of Kuwait, Safat, Kuwait.
Biol Psychiatry. 1996 Dec 1;40(11):1128-31. doi: 10.1016/S0006-3223(95)00599-4.
This study compared the serum lipid concentrations in 100 patients with major depressive disorder (MDD) with those from 100 matched healthy controls. It was found that the serum total cholesterol concentration in patients with MDD (5.27 +/- 1.18 mmol/L) was significantly lower than the value (6.63 +/- 1.32 mmol/L) in sex-, age-, and weight-matched healthy controls. This significant decrease in serum cholesterol in patients with MDD was noted in both sexes and in all age groups. Patients with MDD, however, had significantly higher HDL cholesterol than matched controls. There were no statistically significant differences in serum concentrations of triglycerides, apolipoprotein (Apo) A1, Apo B, transferrin, and albumin between patients and controls. Clinical recovery of patients with MDD was accompanied by a significant increase in serum total cholesterol from 5.27 +/- 1.18 mmol/L to 6.12 +/- 1.2 mmol/L. These results suggest an association between low serum total cholesterol and depression in both sexes and at all age groups.
本研究比较了100例重度抑郁症（MDD）患者与100例匹配的健康对照者的血脂浓度。结果发现，MDD患者的血清总胆固醇浓度（5.27±1.18 mmol/L）显著低于性别、年龄和体重匹配的健康对照者的值（6.63±1.32 mmol/L）。MDD患者血清胆固醇的这种显著降低在男女两性和所有年龄组中均有发现。然而，MDD患者的高密度脂蛋白胆固醇显著高于匹配的对照者。患者与对照者之间的血清甘油三酯、载脂蛋白（Apo）A1、Apo B、转铁蛋白和白蛋白浓度无统计学显著差异。MDD患者的临床康复伴随着血清总胆固醇从5.27±1.18 mmol/L显著增加至6.12±1.2 mmol/L。这些结果表明，血清总胆固醇水平低与各年龄组男女的抑郁症之间存在关联。
