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Antipsychotic drug effects in a model of schizophrenic attentional disorder: a randomized controlled trial of the effects of haloperidol on latent inhibition in healthy people.

作者信息

Williams J H, Wellman N A, Geaney D P, Cowen P J, Feldon J, Rawlins J N

机构信息

Department of Pharmacology, University of Oxford, United Kingdom.

出版信息

Biol Psychiatry. 1996 Dec 1;40(11):1135-43. doi: 10.1016/S0006-3223(95)00629-X.

DOI:10.1016/S0006-3223(95)00629-X
PMID:8931917
Abstract

We studied the effects of haloperidol (0.5 mg, intravenously) on latent inhibition in an auditory paradigm and two visual paradigms in healthy subjects. Haloperidol increased latent inhibition in one visual paradigm and tended to increase latent inhibition in an auditory task, compared to saline-injected controls. These results indicate that haloperidol can enhance the selectivity of attention. In contrast, previous studies have reported that acute schizophrenics show reduced latent inhibition.

摘要

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