Inselman L S, Mellins R B, Brasel J A
J Appl Physiol Respir Environ Exerc Physiol. 1977 Jul;43(1):27-31. doi: 10.1152/jappl.1977.43.1.27.
The effect of unilateral lung collapse on compensatory lung growth was studied in 3-wk-old (young) and 10-wk-old (adult) male Long-Evans rats. Under light halothane anesthesia, left lung collapse was produced by injection of dental plastic through a thracheostomy cannula. The rats were killed either 5 days or 4 wk later. At 5 days postcollapse, the 3-wk-old rats had an increase in DNA over sham controls (21%) (P less than 0.05), with no significant change in the protein/DNA ratio. At 4 wk postcollapse, increases in DNA over shamoperated controls were observed in both the 3-wk-old (58%) and the 10-wk-old (28%) rats, whereas the protein/DNA ratio at both ages was significantly less than that of sham controls (P less than 0.05). Thus, unilateral lung collapse stimulates growth of the contralateral lung by cellular hyperplasia, not hypertrophy, both in the young and adult rat. The hyperplasia begins within 5 days after collapse and is greater by 4 wk. The extent of hyperplasia is greater in the young than in the adult rat.
在3周龄（幼年）和10周龄（成年）雄性Long-Evans大鼠中研究了单侧肺萎陷对代偿性肺生长的影响。在轻度氟烷麻醉下，通过气管造口插管注入牙科塑料造成左肺萎陷。5天或4周后处死大鼠。肺萎陷后5天，3周龄大鼠的DNA含量比假手术对照组增加（21%）（P<0.05），蛋白质/DNA比值无显著变化。肺萎陷后4周，3周龄（58%）和10周龄（28%）大鼠的DNA含量均比假手术对照组增加，而两个年龄段的蛋白质/DNA比值均显著低于假手术对照组（P<0.05）。因此，无论是幼年大鼠还是成年大鼠，单侧肺萎陷均通过细胞增生而非肥大刺激对侧肺生长。增生在萎陷后5天内开始，4周时更明显。幼年大鼠的增生程度大于成年大鼠。
