Lopata M, Evanich M J, Lourenço R V
Am Rev Respir Dis. 1977 Sep;116(3):449-55. doi: 10.1164/arrd.1977.116.3.449.
We determined the relationship between mouth occlusion pressure and diaphragmatic electromyography during CO2 rebreathing with and without inspiratory flow resistance. Diaphragmatic electromyography was measured as a moving time average; occlusion pressures were measured 150 msec after onset of an inspiratory effort against a closed airway (P.15). P.15 versus diaphragmatic electromyographic plots during CO2 rebreathing with and without inspiratory flow resistance were linear. In 3 subjects the slope of P.15 versus diaphragmatic electromyography was unchanged with inspiratory flow resistance whereas in 3 others the slope increased, indicating greater inspiratory force for a given degree of diaphragmatic activity. We concluded that under unloaded conditions P.15 is a reliable index of respiratory neural output but may no longer reflect only inspiratory motoneuron drive during mechanical loading.
我们测定了在有和没有吸气气流阻力的情况下，二氧化碳重复呼吸期间口腔闭塞压与膈肌肌电图之间的关系。膈肌肌电图以移动时间平均值来测量；闭塞压在对抗闭合气道进行吸气努力开始后150毫秒测量（P.15）。在有和没有吸气气流阻力的二氧化碳重复呼吸期间，P.15与膈肌肌电图的关系图呈线性。在3名受试者中，P.15与膈肌肌电图的斜率在有吸气气流阻力时保持不变，而在另外3名受试者中斜率增加，这表明在给定程度的膈肌活动时吸气力更大。我们得出结论，在无负荷条件下，P.15是呼吸神经输出的可靠指标，但在机械负荷期间可能不再仅反映吸气运动神经元驱动。
