Janssen P L, Meyboom S, van Staveren W A, de Vegt F, Katan M B
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
Eur J Clin Nutr. 1996 Nov;50(11):772-4.
Ginger (Zingiber Officinale Roscoe) has been claimed to exert an anti-thrombotic effect in humans as ginger extracts inhibit cyclo-oxygenase activity of platelets in vitro. Effects of ginger consumption on ex vivo platelet function, however, are contradictory. We therefore investigated whether daily consumption of raw or cooked ginger decreases platelet cyclo-oxygenase activity as assessed by ex vivo maximally stimulated platelet thromboxane B2 production.
We carried out a randomized placebo-controlled cross-over study of 3 x 2 weeks.
Eighteen healthy volunteers aged 22 +/- 3 y (mean +/- s.d.) participated in the study; there were no dropouts.
Subjects consumed 15 g of raw ginger root, 40 g of cooked stem ginger, or placebo daily for two weeks. We took fasted venous blood samples and measured thromboxane B2 production in maximally stimulated platelet-rich plasma at days 12 and 14 of each treatment period.
Mean decrease in thromboxane production relative to placebo was 1 +/- 9% for ginger root, and -1 +/- 8% for stem ginger, with no effect of treatment order (P = 0.984).
We cannot confirm the putative anti-thrombotic activity of ginger in humans.
姜（姜科植物姜）据称对人体具有抗血栓形成作用，因为姜提取物在体外可抑制血小板的环氧化酶活性。然而，食用姜对体外血小板功能的影响存在矛盾。因此，我们研究了每日食用生姜或熟姜是否会降低血小板环氧化酶活性，这通过体外最大刺激血小板血栓素B2生成来评估。
我们进行了一项为期3×2周的随机安慰剂对照交叉研究。
18名年龄在22±3岁（均值±标准差）的健康志愿者参与了该研究；无脱落病例。
受试者每天食用15克生姜根、40克熟干姜或安慰剂，持续两周。在每个治疗期的第12天和第14天，采集空腹静脉血样本，并测量最大刺激富含血小板血浆中的血栓素B2生成。
相对于安慰剂，姜根使血栓素生成的平均降低幅度为1±9%，干姜为-1±8%，治疗顺序无影响（P = 0.984）。
我们无法证实姜在人体中假定的抗血栓活性。
