Janssen P L, Akkerman J W, Hollman P C, van Staveren W A, Zwaginga J J, Katan M B
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
Eur J Clin Nutr. 1995 May;49(5):365-70.
It has been suggested that certain foods of plant origin contain milligram-quantities of acetylsalicylate which could exert an anti-thrombotic effect. Acetylsalicylic acid prevents cardiovascular diseases through inhibition of platelet endoperoxide thromboxane production and platelet aggregation. We investigated whether a daily intake of 3 mg acetylsalicylic acid causes a measurable decrease of platelet cyclo-oxygenase activity assessed by in vitro thromboxane B2 production.
We carried out a randomised, double-blind, placebo-controlled cross-over study.
Ten healthy volunteers (5 men, 5 women) aged 22 +/- 3 years (mean +/- s.d) participated in the study; there were no drop-outs.
Participants took 3 mg/d of acetylsalicylic acid or a placebo for 2 weeks each. At the end of each treatment period venous blood was drawn, and platelet-rich plasma was stimulated with arachidonic acid.
Treatment with acetylsalicylic acid caused a 39 +/- 8% decrease in maximal thromboxane B2 production (P = 0.000), which was independent of treatment order.
Quantitative data on acetylsalicylate in foods and the possible antithrombotic action of a diet rich in acetylsalicylate deserve closer investigation.
有人提出某些植物性食物含有毫克量的乙酰水杨酸酯，可能具有抗血栓形成作用。乙酰水杨酸通过抑制血小板内过氧化物血栓素的产生和血小板聚集来预防心血管疾病。我们研究了每日摄入3毫克乙酰水杨酸是否会导致通过体外血栓素B2生成评估的血小板环氧化酶活性出现可测量的下降。
我们进行了一项随机、双盲、安慰剂对照的交叉研究。
10名年龄在22±3岁（平均±标准差）的健康志愿者（5名男性，5名女性）参与了该研究；无退出者。
参与者分别服用3毫克/天的乙酰水杨酸或安慰剂，各为期2周。在每个治疗期结束时采集静脉血，并用花生四烯酸刺激富含血小板的血浆。
乙酰水杨酸治疗使血栓素B2的最大生成量降低了39±8%（P = 0.000），且与治疗顺序无关。
食物中乙酰水杨酸酯的定量数据以及富含乙酰水杨酸酯的饮食可能的抗血栓作用值得进一步研究。
