Laski M E, Kurtzman N A
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 19430, USA.
Miner Electrolyte Metab. 1996;22(5-6):410-22.
The ion-transporting ATPases determine the chemical composition of cells both directly and through their secondary effects. The Na,K-ATPase generates the transmembrane sodium gradient which provides the primary energy for uptake and extrusion of a wide variety of solutes by renal tubular epithelia. The H-ATPase and the H,K-ATPase acidify the urine, and also generates bicarbonate for excretion by the cortical collecting duct. Calcium ATPase regulates the intracellular calcium, which in turn impacts on the myriad of cellular functions for which calcium serves as an intracellular messenger. If one considers the impact of potential pump dysfunction in a purely speculative mode, the list of disorders which might be potentially ascribed to 'pump disease' would be enormous. This article reviews those disorders of renal transport already considered to be 'pump diseases'.
离子转运ATP酶直接或通过其继发效应决定细胞的化学成分。钠钾ATP酶产生跨膜钠梯度，该梯度为肾小管上皮细胞摄取和排出多种溶质提供主要能量。氢ATP酶和氢钾ATP酶使尿液酸化，并为皮质集合管排泄产生碳酸氢盐。钙ATP酶调节细胞内钙，而细胞内钙又会影响众多以钙作为细胞内信使的细胞功能。如果以纯粹推测的方式考虑潜在泵功能障碍的影响，那么可能归因于“泵疾病”的疾病清单将非常庞大。本文综述了那些已被认为是“泵疾病”的肾脏转运疾病。
