Banatvala N, Debeukelaer M M, Griffin P M, Barrett T J, Greene K D, Green J H, Wells J G
Foodborne and Diarrheal Diseases Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Pediatr Infect Dis J. 1996 Nov;15(11):1008-11. doi: 10.1097/00006454-199611000-00015.
To describe a family cluster of Shiga toxin-producing Escherichia coli O111ac:NM infection.
The index case was identified as part of a United States prospective study of hemolytic-uremic syndrome. Epidemiologic investigation was conducted through interviews. E. coli O111:NM infection was characterized through culture and serology. Shiga toxin 1 and 2 gene sequences were determined with oligonucleotide DNA probes.
All three children and both parents had nonbloody diarrhea, vomiting and abdominal cramps, and one child developed hemolytic-uremic syndrome. Shiga toxin 1- and 2-producing E. coli O111ac:NM was isolated from two children. IgG antibodies to E. coli O111 were detected in all three children.
To our knowledge this is the first reported cluster of O111 infection and only the second caused by non-O157 Shiga toxin-producing E. coli in North America.
描述一起产志贺毒素大肠杆菌O111ac:NM感染的家庭聚集性病例。
首例病例是作为美国溶血尿毒综合征前瞻性研究的一部分被识别出来的。通过访谈进行流行病学调查。通过培养和血清学对大肠杆菌O111:NM感染进行特征分析。使用寡核苷酸DNA探针测定志贺毒素1和2的基因序列。
三个孩子及其父母均出现非血性腹泻、呕吐和腹部绞痛，其中一个孩子发展为溶血尿毒综合征。从两个孩子身上分离出产志贺毒素1和2的大肠杆菌O111ac:NM。在所有三个孩子体内均检测到针对大肠杆菌O111的IgG抗体。
据我们所知，这是首次报道的O111感染聚集性病例，也是北美第二例由非O157产志贺毒素大肠杆菌引起的病例。
