一株缺乏eae基因的产志贺毒素大肠杆菌O113:H21菌株的分子特征分析，该菌株与一系列溶血尿毒综合征病例相关。
Molecular characterization of a Shiga toxigenic Escherichia coli O113:H21 strain lacking eae responsible for a cluster of cases of hemolytic-uremic syndrome.
作者信息
Paton A W, Woodrow M C, Doyle R M, Lanser J A, Paton J C
机构信息
Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, S.A. 5006, Australia.
出版信息
J Clin Microbiol. 1999 Oct;37(10):3357-61. doi: 10.1128/JCM.37.10.3357-3361.1999.
Abstract
Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, certain strains appear to have greater virulence for humans. STEC strains carrying eae and belonging to serogroup O157 or O111 have been responsible for the vast majority of outbreaks of STEC disease reported to date. Here we describe a STEC O113:H21 strain lacking eae that was responsible for a cluster of three cases of hemolytic-uremic syndrome. This strain produces a single Stx2-related toxin and adheres efficiently to Henle 407 cells.
摘要
产志贺毒素大肠杆菌（STEC）菌株是一类能导致人类严重胃肠道疾病的多样生物群体。在STEC家族中，某些菌株对人类似乎具有更强的毒力。携带eae且属于血清型O157或O111的STEC菌株是迄今为止报告的绝大多数STEC疾病暴发的病因。在此，我们描述了一株缺乏eae的STEC O113:H21菌株，它导致了三例溶血性尿毒症综合征病例的聚集。该菌株产生一种单一的与Stx2相关的毒素，并能有效黏附于亨勒407细胞。
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