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一株缺乏eae基因的产志贺毒素大肠杆菌O113:H21菌株的分子特征分析，该菌株与一系列溶血尿毒综合征病例相关。

Molecular characterization of a Shiga toxigenic Escherichia coli O113:H21 strain lacking eae responsible for a cluster of cases of hemolytic-uremic syndrome.

作者信息

Paton A W, Woodrow M C, Doyle R M, Lanser J A, Paton J C

机构信息

Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, S.A. 5006, Australia.

出版信息

J Clin Microbiol. 1999 Oct;37(10):3357-61. doi: 10.1128/JCM.37.10.3357-3361.1999.

DOI:10.1128/JCM.37.10.3357-3361.1999
PMID:10488206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC85566/
Abstract

Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, certain strains appear to have greater virulence for humans. STEC strains carrying eae and belonging to serogroup O157 or O111 have been responsible for the vast majority of outbreaks of STEC disease reported to date. Here we describe a STEC O113:H21 strain lacking eae that was responsible for a cluster of three cases of hemolytic-uremic syndrome. This strain produces a single Stx2-related toxin and adheres efficiently to Henle 407 cells.

摘要

产志贺毒素大肠杆菌（STEC）菌株是一类能导致人类严重胃肠道疾病的多样生物群体。在STEC家族中，某些菌株对人类似乎具有更强的毒力。携带eae且属于血清型O157或O111的STEC菌株是迄今为止报告的绝大多数STEC疾病暴发的病因。在此，我们描述了一株缺乏eae的STEC O113:H21菌株，它导致了三例溶血性尿毒症综合征病例的聚集。该菌株产生一种单一的与Stx2相关的毒素，并能有效黏附于亨勒407细胞。

相似文献

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Molecular characterization of a Shiga toxigenic Escherichia coli O113:H21 strain lacking eae responsible for a cluster of cases of hemolytic-uremic syndrome.一株缺乏eae基因的产志贺毒素大肠杆菌O113:H21菌株的分子特征分析，该菌株与一系列溶血尿毒综合征病例相关。
J Clin Microbiol. 1999 Oct;37(10):3357-61. doi: 10.1128/JCM.37.10.3357-3361.1999.
2
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本文引用的文献

1
Molecular characterization of the locus encoding biosynthesis of the lipopolysaccharide O antigen of Escherichia coli serotype O113.大肠杆菌O113血清型脂多糖O抗原生物合成相关基因座的分子特征分析
Infect Immun. 1999 Nov;67(11):5930-7. doi: 10.1128/IAI.67.11.5930-5937.1999.
2
Direct detection of Shiga toxigenic Escherichia coli strains belonging to serogroups O111, O157, and O113 by multiplex PCR.通过多重聚合酶链反应直接检测属于血清群O111、O157和O113的产志贺毒素大肠杆菌菌株。
J Clin Microbiol. 1999 Oct;37(10):3362-5. doi: 10.1128/JCM.37.10.3362-3365.1999.
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Molecular analysis of Shiga toxigenic Escherichia coli O111:H- proteins which react with sera from patients with hemolytic-uremic syndrome.与溶血尿毒综合征患者血清发生反应的产志贺毒素大肠杆菌O111:H-蛋白的分子分析
Infect Immun. 1998 Apr;66(4):1467-72. doi: 10.1128/IAI.66.4.1467-1472.1998.
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Detection and characterization of Shiga toxigenic Escherichia coli by using multiplex PCR assays for stx1, stx2, eaeA, enterohemorrhagic E. coli hlyA, rfbO111, and rfbO157.通过使用针对stx1、stx2、eaeA、肠出血性大肠杆菌hlyA、rfbO111和rfbO157的多重聚合酶链反应（PCR）检测法来检测和鉴定志贺毒素产生型大肠杆菌并进行特性分析。
J Clin Microbiol. 1998 Feb;36(2):598-602. doi: 10.1128/JCM.36.2.598-602.1998.
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Diarrheagenic Escherichia coli.致泻性大肠杆菌
Clin Microbiol Rev. 1998 Jan;11(1):142-201. doi: 10.1128/CMR.11.1.142.
7
Shiga toxin-producing Escherichia coli isolates from cases of human disease show enhanced adherence to intestinal epithelial (Henle 407) cells.从人类疾病病例中分离出的产志贺毒素大肠杆菌菌株对肠道上皮（亨勒407）细胞的黏附性增强。
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Possible person-to-person transmission of Escherichia coli O111--associated hemolytic uremic syndrome.
Pediatr Nephrol. 1997 Feb;11(1):36-9. doi: 10.1007/s004670050229.
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Shiga-like toxin-producing Escherichia coli O111 and associated hemolytic-uremic syndrome: a family outbreak.产志贺毒素大肠杆菌O111与相关溶血尿毒综合征：一次家庭暴发
Pediatr Infect Dis J. 1996 Nov;15(11):1008-11. doi: 10.1097/00006454-199611000-00015.
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Molecular microbiological investigation of an outbreak of hemolytic-uremic syndrome caused by dry fermented sausage contaminated with Shiga-like toxin-producing Escherichia coli.一起由受产志贺毒素大肠杆菌污染的干发酵香肠引发的溶血尿毒综合征暴发的分子微生物学调查。
J Clin Microbiol. 1996 Jul;34(7):1622-7. doi: 10.1128/JCM.34.7.1622-1627.1996.