从人脑中分离并鉴定一种新型三唾液酸神经节苷脂GT1a
Isolation and characterization of a novel trisialoganglioside, GT1a, from human brain.
作者信息
Ando S, Yu R K
出版信息
J Biol Chem. 1977 Sep 25;252(18):6247-50.
PMID:893404
Abstract
A novel trisialoganglioside has been isolated from normal adult human brain in a yield of 0.6% of the total gangkioside. By graded neuraminidase treatment, mild acid hydrolysis and periodate oxidation analysis, the ganglioside was identified as GT1a having the following structure: NeuAc(alpha, 2-8)NeuAc(alpha, 2-3)Gal(beta, 1-3)GalNAc(beta, 1-4) [NeuAc(alpha, 2-3)]Gal(beta, 1-4)Glc(1-1)ceramide.
摘要
从正常成年人脑中分离出一种新型三唾液酸神经节苷脂，其产量占总神经节苷脂的0.6%。通过分级神经氨酸酶处理、温和酸水解和高碘酸盐氧化分析，该神经节苷脂被鉴定为具有以下结构的GT1a：NeuAc(α,2-8)NeuAc(α,2-3)Gal(β,1-3)GalNAc(β,1-4)[NeuAc(α,2-3)]Gal(β,1-4)Glc(1-1)神经酰胺。
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