儿童中2%和4%阿替卡因的血清水平。
Serum levels of articaine 2% and 4% in children.
作者信息
Jakobs W, Ladwig B, Cichon P, Ortel R, Kirch W
机构信息
Privatuniversität Witten, Germany.
出版信息
Anesth Prog. 1995;42(3-4):113-5.
Abstract
The results of the present study of the pharmacokinetics of articaine in children show serum concentrations comparable to those in adults. The maximum values are distinctly lower with the 2% articaine solution. The t max found in our investigation was distinctly earlier than in comparable investigations on adults, whereas the plasma clearance was increased. There is no need to fix a lower mg/kg articaine dose limit for children because of age-related differences in the pharmacokinetics. The use of 2% articaine in pediatric dentistry is particularly advantageous because of the lower C max and the shorter half-life.
摘要
本次关于儿童阿替卡因药代动力学的研究结果表明，其血清浓度与成人相当。2%阿替卡因溶液的最大值明显较低。我们研究中发现的达峰时间明显早于针对成人的类似研究，而血浆清除率有所增加。由于药代动力学存在与年龄相关的差异，无需为儿童设定较低的阿替卡因毫克/千克剂量限制。在儿童牙科中使用2%阿替卡因特别有利，因为其最大血药浓度较低且半衰期较短。
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本文引用的文献
1
[Clinical pharmacokinetics of Articain after intraoral and intramuscular applications].
SSO Schweiz Monatsschr Zahnheilkd. 1983 Sep;93(9):714-9.
2
Technical considerations in the use of "high-performance" liquid chromatography in therapeutic drug monitoring.
Clin Chem. 1983 Jul;29(7):1331-43.
3
[Pharmacokinetics of articaine in mandibular nerve block].
Reg Anaesth. 1991 May;14(3):52-5.
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