Chan L, Balabaskaran S, Delilkan A E, Ong L H
Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Malays J Pathol. 1994 Dec;16(2):161-4.
Data on blood cholinesterase levels in the Malaysian population is lacking. The spectrophotometric method of Ellman was used to determine the red cell, plasma and whole blood cholinesterase (ChE) levels in 407 Malaysian blood donors. The mean+1SD for plasma ChE in females (n = 48) was 2.37 + 0.70 umol/min/ml and 2.76 + 0.75 umol/min/ml in males (n = 359). The mean plasma ChE in males was higher than in females (p < 0.001). The mean+1SD for red cell ChE in females was 9.01 + 1.20 umol/min/ml whereas in males it was 7.69 +1.30 umol/min/ml (the mean red cell ChE in females was higher than in males, p < 0.0001). The mean+1SD for whole blood ChE for females was 4.31+ 0.58 umol/min/ml and for males it was 4.95 + 0.71 umol/min/ml. The mean whole blood ChE in males was higher than in females (p < 0.0001). Sex influenced the plasma, red cell and whole blood ChE. In males the plasma ChE was affected by the race factor. The mean+1SD plasma ChE for the Malay, Chinese and Indian were 2.92 + 0.80, 2.73 + 0.71 and 2.61+ 0.73 respectively (p < 0.002). The age factor in males affected the red cell ChE with 7.88 + 1.32 in the (30-69) age group and 7.47 + 1.23 in the (15-29) age group (p < 0.005). The whole blood ChE in females was affected by blood groups. The mean+1SD whole blood ChE for blood groups A,B and O were 4.19 + 0.42, 3.93 + 0.46 and 4.49 + 0.62 respectively (p < 0.03). The significant difference is between the ChE of group B and O, but the ChE of group A could not be determined to be different from group B or O. These results serve as guidelines for our local population in the evaluation of cholinesterase levels with regard to pesticide poisoning, liver biosynthetic capacity and unusual sensitivity to succinylcholine.
马来西亚人群血液胆碱酯酶水平的数据尚缺。采用埃尔曼分光光度法测定了407名马来西亚献血者的红细胞、血浆和全血胆碱酯酶（ChE）水平。女性（n = 48）血浆ChE的均值±1标准差为2.37±0.70微摩尔/分钟/毫升，男性（n = 359）为2.76±0.75微摩尔/分钟/毫升。男性的平均血浆ChE高于女性（p < 0.001）。女性红细胞ChE的均值±1标准差为9.01±1.20微摩尔/分钟/毫升，而男性为7.69±1.30微摩尔/分钟/毫升（女性的平均红细胞ChE高于男性，p < 0.0001）。女性全血ChE的均值±1标准差为4.31±0.58微摩尔/分钟/毫升，男性为4.95±0.71微摩尔/分钟/毫升。男性的平均全血ChE高于女性（p < 0.0001）。性别影响血浆、红细胞和全血ChE。在男性中，血浆ChE受种族因素影响。马来人、华人及印度人的平均±1标准差血浆ChE分别为2.92±0.80、2.73±0.71和2.61±0.73（p < 0.002）。男性的年龄因素影响红细胞ChE，（30 - 69）岁年龄组为7.88±1.32，（15 - 29）岁年龄组为7.47±1.23（p < 0.005）。女性的全血ChE受血型影响。A、B和O血型的平均±1标准差全血ChE分别为4.19±0.42、3.93±0.46和4.49±0.62（p < 0.03）。显著差异存在于B组和O组的ChE之间，但无法确定A组的ChE与B组或O组不同。这些结果可为我们当地人群在评估胆碱酯酶水平以诊断农药中毒、肝脏生物合成能力及对琥珀酰胆碱的异常敏感性方面提供指导。
