Blier P, Slater S, Measham T, Koch M, Wiviott G
Department of Psychiatry, McGill University, Montréal, Quebec, Canada.
Int Clin Psychopharmacol. 1998 May;13(3):137-40. doi: 10.1097/00004850-199805000-00008.
Lithium administration was used in a patient with a clozapine-induced neutropenia and in another with complete agranulocytosis to assess whether lithium could stimulate neutrophil production. In both cases, following lithium administration, the neutrophil count was increased to the normal range within 6 days. In the patient who had presented a neutropenia, clozapine treatment was then reinstated in the presence of lithium and continued without the neutrophil count dropping into the yellow-alert range thereafter.
锂盐被用于一名氯氮平诱导的中性粒细胞减少症患者以及另一名完全性粒细胞缺乏症患者，以评估锂盐是否能刺激中性粒细胞生成。在这两个病例中，给予锂盐后，中性粒细胞计数在6天内升至正常范围。在出现中性粒细胞减少症的患者中，随后在锂盐存在的情况下恢复氯氮平治疗，此后继续治疗，中性粒细胞计数未降至黄色警戒范围。
