Xi X R, Qureshi I A, Wu X D, Huang Y B, Lu H, Shiarkar E
School of Basic Medical Sciences, Shanghai Medical University, People's Republic of China.
J Pak Med Assoc. 1996 Aug;46(8):171-4.
This study evaluated the distribution of Intraocular pressure (IOP) levels in 67 normal and 59 ocular hypertensive (OHT) subjects during the day after placing control on all those factors that can affect IOP. The IOP was measured with the Goldmann applanation tonometer. All the subjects were examined according to standard protocols. Both in the normal and OHT subjects, the peak of mean IOP appeared in the morning when the subjects woke up and the trough of mean IOP occurred between 2 a.m. to 4 a.m. The mean diurnal variation were (mean +/- sem) 2.9 +/- 0.7 and 3.5 +/- 0.7 mmHg in the normal and in OHT subjects, respectively. Ninety-four percent of the normal subjects and sixty-eight percent of the OHT subjects exhibited a similar diurnal behaviour in both eyes. The IOP variation did not correlate with the variations of blood pressure. The diurnal variation of IOP, found in Chinese, is lower than in other nations. The clinical importance of findings that the peaks of IOP occur in the early morning, raised a serious question as to the necessity of extending the diurnal IOP curves beyond the usual working time (JPMA 46:171, 1996).
本研究评估了67名正常受试者和59名高眼压症（OHT）受试者在控制所有可能影响眼压的因素后的白天眼压水平分布情况。眼压采用Goldmann压平眼压计测量。所有受试者均按照标准方案进行检查。在正常受试者和高眼压症受试者中，平均眼压峰值均出现在早晨受试者醒来时，平均眼压谷值出现在凌晨2点至4点之间。正常受试者和高眼压症受试者的平均昼夜眼压波动分别为（均值±标准误）2.9±0.7和3.5±0.7 mmHg。94%的正常受试者和68%的高眼压症受试者双眼呈现相似的昼夜眼压变化规律。眼压变化与血压变化无关。中国人的眼压昼夜波动低于其他国家。眼压峰值出现在清晨这一发现的临床重要性，引发了关于将昼夜眼压曲线测量时间延长至常规工作时间以外的必要性的严重质疑（《巴基斯坦医学协会杂志》46:171, 1996）。
