Tan Y, Ogawa H
Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College.
Masui. 1996 Oct;45(10):1223-34.
The effect of superior cervical sympathetic ganglionectomy (SCGx) on FSH, LH and GH cells of the adenohypophysis was investigated in normal and ovariectomized prepubertal female rats by immunohistochemistry and morphometry. At 2 weeks after SCGx in normal rats, FSH and LH cells increased in number and in immunostaining density: these indicate augmentation of their functional activity. These increases almost disappeared at 4-8 weeks after SCGx. After ovariectomy FSH and LH cells showed reduction of immunoreactive density, cell enlargement, vacuolation and increase of cell number. SCGx suppressed the morphological changes of both cells. GH cell number decreased at 2 weeks after SCGx in normal and ovariectomized rats, but after 4-8 weeks, the number was restored. The present data indicate that cervical sympathetic nervous system exerts a different influence on endocrine system, which depends on the types and activities of the cells in adenohypophysis. Sympathetic nervous system can play an important role of maintaining and regulating of the secretory function of the adenohypophysis.
通过免疫组织化学和形态计量学方法，研究了颈上神经节切除术（SCGx）对正常和去卵巢青春期前雌性大鼠腺垂体中促卵泡激素（FSH）、促黄体生成素（LH）和生长激素（GH）细胞的影响。在正常大鼠中，SCGx术后2周，FSH和LH细胞数量及免疫染色密度增加：这表明其功能活性增强。这些增加在SCGx术后4 - 8周几乎消失。去卵巢后，FSH和LH细胞免疫反应密度降低、细胞增大、出现空泡化且细胞数量增加。SCGx抑制了这两种细胞的形态学变化。在正常和去卵巢大鼠中，SCGx术后2周GH细胞数量减少，但4 - 8周后数量恢复。目前的数据表明，颈交感神经系统对内分泌系统有不同的影响，这取决于腺垂体中细胞的类型和活性。交感神经系统在维持和调节腺垂体的分泌功能中可发挥重要作用。
