DuBose T D, Codina J
Division of Renal Diseases and Hypertension, University of Texas Medical School-Houston, Houston 77030, USA.
Curr Opin Nephrol Hypertens. 1996 Sep;5(5):411-6. doi: 10.1097/00041552-199609000-00006.
At least four unique H,K-ATPases have been cloned and are expressed in several tissues. Recent findings have enhanced our appreciation of the roles of H,K-ATPases in the kidney with respect to their molecular identities, functional properties, segmental and intrarenal distribution, and regulatory features. The major role of the H,K-ATPases expressed in mammalian kidney, the gastric and colonic H,K-ATPases, is to regulate potassium and bicarbonate absorption in collecting duct segments.
至少已克隆出四种独特的H，K - ATP酶，并在多种组织中表达。最近的研究结果使我们对H，K - ATP酶在肾脏中的作用有了更深入的认识，包括它们的分子特性、功能特性、节段性和肾内分布以及调节特征。在哺乳动物肾脏中表达的H，K - ATP酶（胃和结肠H，K - ATP酶）的主要作用是调节集合管节段中的钾和碳酸氢盐吸收。
