Dommergues M, Mahieu-Caputo D, Fallet-Bianco C, Mirlesse V, Aubry M C, Delezoide A L, Dumez Y, Lebon P
Maternité Port-Royal Baudelocque, Hôpital Cohin, Paris, France.
Prenat Diagn. 1996 Oct;16(10):883-92. doi: 10.1002/(SICI)1097-0223(199610)16:10<883::AID-PD959>3.0.CO;2-5.
We assayed fetal serum interferon-alpha (IFNA), a cytokine produced by leukocytes as a response to viral infection, in a series of 59 consecutive cases of ventriculomegaly diagnosed in utero and in 89 controls. Results were correlated with other findings including karyotype, maternal-fetal screening for serum antibodies to specific infectious pathogens, viral cultures of amniotic fluid, and neuropathological examination or postnatal follow-up. Fetal serum IFNA assay was negative in the five ventriculomegalies associated with a genetic anomaly and positive in the three cases with documented cytomegalovirus infections. In addition, fetal serum IFNA was detected significantly more often in the cases of ventriculomegaly with unexplained pathogenesis (15/51, 29.4 per cent) than in controls (1/89, 1.1 per cent). Detection of IFNA suggestive of viral infection in fetuses with otherwise unexplained ventriculomegaly underscores the need for more extensive viral screening in such cases.
我们对一系列连续59例产前诊断为脑室扩大的病例及89例对照者检测了胎儿血清α干扰素（IFNA），这是一种白细胞产生的针对病毒感染的细胞因子。结果与其他检查结果相关，包括核型分析、母婴血清特异性感染病原体抗体筛查、羊水病毒培养以及神经病理学检查或出生后随访。与基因异常相关的5例脑室扩大病例中胎儿血清IFNA检测为阴性，3例有明确巨细胞病毒感染的病例中检测为阳性。此外，病因不明的脑室扩大病例（15/51，29.4%）中胎儿血清IFNA的检测频率显著高于对照组（1/89，1.1%）。在病因不明的脑室扩大胎儿中检测到提示病毒感染的IFNA，突出了对此类病例进行更广泛病毒筛查的必要性。
