Moeholt K, Aagaard H, Pfeiffer P, Hansen O
Department of Oncology, Aalborg Municipal Hospital, Denmark.
Acta Oncol. 1996;35(6):677-82. doi: 10.3109/02841869609083998.
Systemic cytotoxic therapy with platinum containing regimens has been reviewed in 53 patients with progressive disease of basal cell carcinoma. The overall response rate in 46 evaluable patients was 83% with complete remission obtained in 17 patients (37%), and partial remission in 21 patients (46%). Eight patients (17%) did not respond to platinum containing therapy. The median observation time was 26 months and the median time to progression 24 months. The median number of courses was 3 (range 2 to 12), and objective response was seen after median 2 courses (range 1 to 6). Platinum-based systemic chemotherapy, either alone or in combination with other therapeutic modalities, may be indicated as treatment of basal cell carcinoma when local therapy is inadequate, or in the rare cases with advanced lesions or metastatic disease.
对53例基底细胞癌病情进展的患者进行了含铂方案的全身细胞毒性治疗评估。46例可评估患者的总缓解率为83%，其中17例（37%）完全缓解，21例（46%）部分缓解。8例（17%）患者对含铂治疗无反应。中位观察时间为26个月，中位进展时间为24个月。中位疗程数为3（范围2至12），中位2个疗程（范围1至6）后出现客观缓解。当局部治疗不足时，或在罕见的晚期病变或转移性疾病病例中，含铂的全身化疗单独或与其他治疗方式联合，可作为基底细胞癌的治疗方法。
