Taravel M N, Domard A
Laboratoire d'Etudes des Materiaux Plastiques et des Biomateriaux, Universite Claude Bernard Lyon I, Villeurbanne, France.
Biomaterials. 1996 Feb;17(4):451-5. doi: 10.1016/0142-9612(96)89663-3.
Bovine atelocollagen and high molecular weight fully deacetylated chitosan, depending on the conditions, can form complexes whether by means of purely electrostatic interactions or by hydrogen bonding. In the first case the maximum proportion of chitosan in the complex is relatively low (approximately 10%) and then it is difficult to conclude whether chitosan prevents collagen digestion by collagenase or not. On the contrary, in the case of the second kind of complex, chitosan induces a strong protection toward the specific enzyme. If we consider the mechanical properties of polyanion/polycation complexes, chitosan brings softening rather than hardening to the system and the complex behaves like some polymer blends.
牛去端胶原和高分子量的完全脱乙酰壳多糖，根据条件不同，可通过纯粹的静电相互作用或氢键作用形成复合物。在第一种情况下，复合物中壳多糖的最大比例相对较低（约10%），因此很难确定壳多糖是否能防止胶原酶对胶原蛋白的消化。相反，在第二种复合物的情况下，壳多糖对特定酶具有很强的保护作用。如果考虑聚阴离子/聚阳离子复合物的机械性能，壳多糖会使体系软化而非硬化，且该复合物的行为类似于某些聚合物共混物。
