Vrecl M, Jan J, Pogacnik A, Bavdek S V
Institute of Anatomy, Histology and Embryology, Veterinary Faculty, University of Ljubljans, Slovenia.
Chemosphere. 1996 Dec;33(11):2341-6. doi: 10.1016/0045-6535(96)00326-8.
The transfer coefficients of tetra- and hexachlorobiphenyls (PCB-54; -80; -155; and -169), HCB and 4,4'-DDE between milk and blood were monitored for eight weeks in sheep previously administered with these compounds by intramuscular injection. Analyses were performed by high resolution gas chromatography. The milk/blood ratio on a fat basis was close to 1 for HCB, over 1 for 4,4'-DDE, PCB-155, and -169 and below 1 for PCB-54 and -80. It is speculated that the deviation from the ratio 1 results from the interactions of organochlorines with (lipo)proteins in blood and/or milk. In milk, the enrichment of 4,4'-DDE, PCB-155 and -169 was observed. The relative toxicity expressed by the toxic equivalent (on a fat basis) was approximately 2.5 times higher in milk than in blood.
对先前通过肌肉注射给予这些化合物的绵羊，监测了四氯和六氯联苯（PCB - 54、- 80、- 155和- 169）、六氯苯（HCB）以及4,4'-滴滴伊（4,4'-DDE）在牛奶和血液之间的转移系数，为期八周。通过高分辨率气相色谱法进行分析。以脂肪为基础，HCB的奶/血比接近1，4,4'-DDE、PCB - 155和- 169的奶/血比大于1，而PCB - 54和- 80的奶/血比低于1。据推测，与1的比值出现偏差是由于有机氯与血液和/或牛奶中的（脂）蛋白相互作用所致。在牛奶中，观察到了4,4'-DDE、PCB - 155和- 169的富集。以脂肪为基础，用毒性当量表示的相对毒性在牛奶中比在血液中约高2.5倍。
