Alton E W, Norris A A
Ion Transport Unit, National Heart and Lung Institute, London, United Kingdom.
J Allergy Clin Immunol. 1996 Nov;98(5 Pt 2):S102-5; discussion S105-6.
Nedocromil sodium has been shown to be capable of inhibiting chloride ion flux in mast cells, epithelial cells, and neurons. This feature may explain how it can prevent responses such as mast-cell degranulation, the effects of osmolarity changes in the airways, and neuronal activation. This mechanism may also provide a unifying hypothesis to explain the effects of nedocromil sodium on a range of cell types involved in asthma, such as sensory and efferent neurons and cells involved in inflammation.
奈多罗米钠已被证明能够抑制肥大细胞、上皮细胞和神经元中的氯离子通量。这一特性或许可以解释它如何预防诸如肥大细胞脱颗粒、气道渗透压变化的影响以及神经元激活等反应。这一机制也可能提供一个统一的假说，用以解释奈多罗米钠对一系列参与哮喘的细胞类型的作用，比如感觉神经元、传出神经元以及参与炎症的细胞。
