Sudbery P E
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
Curr Opin Biotechnol. 1996 Oct;7(5):517-24. doi: 10.1016/s0958-1669(96)80055-3.
The methylotrophic yeasts Hansenula polymorpha and Pichia pastoris are rapidly becoming the systems of choice for the expression of recombinant proteins in yeast. However, the powerful genetic techniques available in Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe are still exploited to establish models to study medically important cell processes and screen for pharmacologically active compounds.
多形汉逊酵母和巴斯德毕赤酵母这两种甲基营养型酵母正迅速成为酵母中重组蛋白表达的首选系统。然而，酿酒酵母和裂殖酵母中可用的强大遗传技术仍被用于建立模型，以研究具有医学重要性的细胞过程，并筛选具有药理活性的化合物。
