Lew D J, Kornbluth S
Department of Molecular Cancer Biology, Box 3686, Duke University Medical Center, Durham, NC 27710, USA.
Curr Opin Cell Biol. 1996 Dec;8(6):795-804. doi: 10.1016/s0955-0674(96)80080-9.
Cyclins and cyclin-dependent kinases (Cdks) are universal regulators of cell cycle progression in eukaryotic cells. Cdk activity is controlled by phosphorylation at three conserved sites, and many of the enzymes that act on these sites have now been identified. Although the biochemistry of Cdk phosphorylation is relatively well understood, the regulatory roles of such phosphorylation are, in many cases, obscure. Recent studies have uncovered new and unexpected potential roles, and prompted re-examination of previously assumed roles, of Cdk phosphorylation.
细胞周期蛋白和细胞周期蛋白依赖性激酶（Cdks）是真核细胞中细胞周期进程的通用调节因子。Cdk活性受三个保守位点磷酸化的控制，目前已鉴定出许多作用于这些位点的酶。尽管Cdk磷酸化的生物化学相对较为清楚，但在许多情况下，这种磷酸化的调节作用仍不清楚。最近的研究揭示了Cdk磷酸化新的和意想不到的潜在作用，并促使人们重新审视其先前假定的作用。
