Morgan D O
Department of Physiology, Box 0444, University of California, 513 Parnassus Ave, San Francisco, CA 94143, USA.
Curr Opin Cell Biol. 1996 Dec;8(6):767-72. doi: 10.1016/s0955-0674(96)80076-7.
In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition by the inhibitor p27, and binding by the CKS proteins.
在过去的一年里，一些新的晶体结构为细胞周期蛋白依赖性激酶调控背后的构象变化提供了令人兴奋的见解。我们现在了解了细胞周期蛋白依赖性激酶多种调控机制的结构基础，包括通过细胞周期蛋白结合和磷酸化激活、被抑制剂p27抑制以及与CKS蛋白结合。
