Tsai K S, Pan W H, Hsu S H, Cheng W C, Chen C K, Chieng P U, Yang R S, Twu S T
Department of Laboratory Medicine, National Taiwan University Hospital. #7, Chung-Shan South Road, 100 Taipei, Taiwan, R.O.C.
Calcif Tissue Int. 1996 Dec;59(6):454-60. doi: 10.1007/BF00369210.
We measured bone mineral density (BMD) at lumbar (L2-L4) vertebrae and proximal femurs of 385 healthy Chinese women aged 40-70 years and 156 healthy Chinese men aged 20-85, and four markers-bone alkaline phosphatase isozyme (BAP), procollagen-I C terminal propeptide (PICP), osteocalcin (BGP) in serum, and a bone resorption marker, urinary cross-linked N-telopeptide of type I collagen (NTX), of these subjects. The results indicate that in postmenopausal women, levels of all the markers increased with age. In men, serum BAP, PICP, and urinary NTX decreased significantly, and serum BGP decreased with borderline significance (P = 0.08). With increasing age, bone density decreased at both sites in postmenopausal women and at the proximal femur in men. The lumbar bone density showed no significant age-related changes in men. In premenopausal women, BMD at either site showed no significant change with increasing age. Despite the different trends between men and women of age-related changes in BMD and bone markers, bone density of both proximal femur and spine in both sexes correlated inversely with levels of the bone markers in a manner independent of age or body weight. The meaning of opposite age effects on bone markers in men and women needs further investigation. In addition, higher bone marker levels, implying faster bone turnover rate, are associated with lower BMD in both sexes.
我们测量了385名年龄在40 - 70岁的健康中国女性和156名年龄在20 - 85岁的健康中国男性的腰椎（L2 - L4）椎体和股骨近端的骨密度（BMD），以及这些受试者的四种标志物——血清中的骨碱性磷酸酶同工酶（BAP）、I型前胶原C端前肽（PICP）、骨钙素（BGP）和一种骨吸收标志物——尿I型胶原交联N端肽（NTX）。结果表明，在绝经后女性中，所有标志物的水平均随年龄增长而升高。在男性中，血清BAP、PICP和尿NTX显著降低，血清BGP降低，差异接近显著水平（P = 0.08）。随着年龄的增长，绝经后女性两个部位的骨密度均下降，男性股骨近端的骨密度下降。男性腰椎骨密度未显示出与年龄相关的显著变化。在绝经前女性中，两个部位的骨密度均未随年龄增长而发生显著变化。尽管男性和女性在骨密度和骨标志物的年龄相关变化趋势不同，但两性股骨近端和脊柱的骨密度均与骨标志物水平呈负相关，且这种相关性与年龄或体重无关。男性和女性骨标志物年龄效应相反的意义需要进一步研究。此外，较高的骨标志物水平意味着更快的骨转换率，这与两性较低的骨密度相关。
