DPY-26，线虫中剂量补偿与减数分裂染色体分离之间的一种联系。
DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode.
作者信息
Lieb J D, Capowski E E, Meneely P, Meyer B J
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
出版信息
Science. 1996 Dec 6;274(5293):1732-6. doi: 10.1126/science.274.5293.1732.
The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well as for proper meiotic chromosome segregation. DPY-26 was shown to mediate both processes through its association with chromosomes. In somatic cells, DPY-26 associates specifically with hermaphrodite X chromosomes to reduce their transcript levels. In germ cells, DPY-26 associates with all meiotic chromosomes to mediate its role in chromosome segregation. The X-specific localization of DPY-26 requires two dosage compensation proteins (DPY-27 and DPY-30) and two proteins that coordinately control both sex determination and dosage compensation (SDC-2 and SDC-3).
在秀丽隐杆线虫中，DPY - 26蛋白对于X染色体剂量补偿以及减数分裂染色体的正确分离是必需的。研究表明，DPY - 26通过与染色体的结合来介导这两个过程。在体细胞中，DPY - 26特异性地与雌雄同体的X染色体结合，以降低其转录水平。在生殖细胞中，DPY - 26与所有减数分裂染色体结合，以介导其在染色体分离中的作用。DPY - 26在X染色体上的特异性定位需要两种剂量补偿蛋白（DPY - 27和DPY - 30）以及两种协调控制性别决定和剂量补偿的蛋白（SDC - 2和SDC - 3）。
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