Weisz-Carrington P, Roux M E, Lamm M E
J Immunol. 1977 Oct;119(4):1306-7.
Mammary glands of virgin, pregnant, lactating, and post-weaning CAF1 mice were studied by immunofluorescence for epithelial immunoglobulins and stromal plasma cells. In normal virgins, both females and males, only occasional plasma cells and but scanty intraepithelial immunoglobulins were present. During pregnancy and the early days of lactation, an increase in the number of plasma cells occurs, and by 1 week of lactation, there is a marked increase in the number, and most are synthesizing IgA. This increment parallels the development and proliferation of the glandular epithelium, in anatomical relation to which the plasma cells are observed. The intraepithelial content of IgA is also maximal when the glandular epithelium is most developed. These findings are consistent with a local production of the IgA in milk. Weaning, or deliberate interruption of suckling for more than 10 days results in a sheep decrease in the number of IgA plasma cells and an involution of the epithelium, whose content of immunoglobulin also declines. The changes in the secretory IgA system which occur locally during lactation are thought to be hormone-dependent.
通过免疫荧光法，对未生育、怀孕、哺乳和断奶后的CAF1小鼠的乳腺进行了研究，以检测上皮免疫球蛋白和基质浆细胞。在正常未生育小鼠中，无论雌雄，仅偶尔有浆细胞存在，上皮内免疫球蛋白也很少。在怀孕期间和哺乳初期，浆细胞数量增加，到哺乳1周时，数量显著增加，且大多数在合成IgA。这种增加与腺上皮的发育和增殖同步，浆细胞在解剖学上与腺上皮相关。当腺上皮最发达时，上皮内IgA含量也最高。这些发现与乳汁中IgA的局部产生一致。断奶或故意停止哺乳超过10天会导致IgA浆细胞数量大幅减少以及上皮退化，其免疫球蛋白含量也会下降。哺乳期局部发生的分泌型IgA系统变化被认为是激素依赖性的。
