Kurihara A, Manabe A, Katsuno K, Itoh K, Hisamitsu H, Wakumoto S, Yoshida T
Department of Operative Dentistry, School of Dentistry, Showa University, Tokyo, Japan.
Dent Mater J. 1996 Dec;15(2):226-32. doi: 10.4012/dmj.15.226.
The purpose of the present study was to evaluate the safety of ethylene glyco (EG) and 1,6-hexanediol (HD) solutions as experimental dentin primers when subjected to the guinea pig maximization test (GPMT), primary irritation test, cumulative skin irritation test and human patch test. No primary and cumulative skin irritation resulting from the use of 62.5% EG or 45% HD solutions was observed. In the case of GPMT, the animals sensitized with 2-hydroxyethyl methacrylate (2-HEMA) responded to 100% HD. 62.5% EG and 45% HD as dentin primers were safer than 2-HEMA such as a methacrylic primer.
本研究的目的是评估乙二醇（EG）和1,6 - 己二醇（HD）溶液作为实验性牙本质引物在进行豚鼠最大化试验（GPMT）、原发性刺激试验、累积皮肤刺激试验和人体斑贴试验时的安全性。未观察到使用62.5% EG或45% HD溶液引起的原发性和累积性皮肤刺激。在GPMT中，用甲基丙烯酸2 - 羟乙酯（2 - HEMA）致敏的动物对100% HD有反应。作为牙本质引物，62.5% EG和45% HD比甲基丙烯酸引物等2 - HEMA更安全。
