Fung Y K, Meade A G, Rack E P, Blotcky A J, Claassen J P, Beatty M W, Durham T
Department of Oral Biology, University of Nebraska Medical Center, College of Dentistry, Lincoln 68538-0740, USA.
Gen Dent. 1996 Jan-Feb;44(1):74-8.
Trace-element neurotoxicity contributing to the development of Alzheimer's disease (AD) may be an important etiologic factor for this disorder. This clinical study was conducted to determine the urine concentrations of mercury (Hg) from patients with AD disorders. Within the confines of a nursing home, all subjects were exposed to the same environment and a diet that excluded seafood. The results of this study do not indicate that subjects with AD have a greater body burden of Hg, according to urinary excretion. This can be further evidence that Hg from amalgam restorations or diet is not related to etiology and pathogenesis of AD.
微量元素神经毒性对阿尔茨海默病（AD）发展的影响可能是该疾病的一个重要病因。本临床研究旨在测定AD患者尿液中的汞（Hg）浓度。在一家养老院范围内，所有受试者都暴露于相同的环境且饮食中不含海鲜。根据尿液排泄情况，本研究结果并未表明AD患者体内汞的负担更重。这可以进一步证明，汞合金修复体或饮食中的汞与AD的病因和发病机制无关。
