Cornett C R, Ehmann W D, Wekstein D R, Markesbery W R
Department of Chemistry, University of Kentucky, Lexington 40506-0055, USA.
Biol Trace Elem Res. 1998 Apr-May;62(1-2):107-14. doi: 10.1007/BF02820026.
Levels of mercury (Hg), selenium (Se), iron (Fe), rubidium (Rb), and zinc (Zn) were measured in the pituitary gland to assess the possibility of a potential difference in the environmental Hg exposure of Alzheimer's disease (AD) patients and control subjects and levels of other elements of interest in AD. The pituitary gland has been established as a good predictor of environmental Hg exposure. Neutron activation analysis was utilized to determine levels of these elements in pituitary glands of 43 AD subjects and 15 control subjects. No significant differences were observed between the AD and control means for these five elements. The sole significant Pearson's correlation involving Hg was the established correlation with Se, indicative of the detoxification of Hg. The absence of a statistical difference between AD and control pituitary gland Hg levels suggests AD patients do not have an excessive environmental exposure to Hg compared to controls.
测量了垂体中汞（Hg）、硒（Se）、铁（Fe）、铷（Rb）和锌（Zn）的含量，以评估阿尔茨海默病（AD）患者和对照受试者在环境汞暴露方面存在潜在差异的可能性，以及AD中其他相关元素的含量。垂体已被确定为环境汞暴露的良好预测指标。采用中子活化分析法测定了43例AD受试者和15例对照受试者垂体中这些元素的含量。这五种元素在AD组和对照组之间未观察到显著差异。唯一与汞有显著相关性的皮尔逊相关性是与硒已确定的相关性，表明汞的解毒作用。AD组和对照组垂体汞含量无统计学差异，这表明与对照组相比，AD患者没有过度的环境汞暴露。
