Thompson L D, Wenig B M, Ellis G L
Department of Otolaryngic and Endocrine Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Cancer. 1996 Dec 1;78(11):2281-7. doi: 10.1002/(sici)1097-0142(19961201)78:11<2281::aid-cncr3>3.0.co;2-q.
Oncocytomas are benign salivary gland neoplasms that represent approximately 1.5% of all salivary gland tumors. Oncocytomas of the submandibular gland, however, are decidedly uncommon.
Twenty-two cases of submandibular gland oncocytomas from the files of the Oral and Otolaryngic Tumor Registries of the Armed Forces Institute of Pathology were reviewed, and analysis of the histologic criteria, histochemical and immunohistochemical reactions, and ultrastructural and clinical follow-up data was performed.
The patients included 11 females and 11 males, age 21-88 years, with a mean age at presentation of 58.7 years. Clinically, the tumors were generally asymptomatic masses in the submandibular gland that increased in size over a period ranging from several weeks to 20 years and were occasionally associated with pain (n = 9). The tumors ranged in greatest dimension from 0.7 to 7 cm and were circumscribed to encapsulated. Histologically, the tumors were characterized by large epithelial cells with eosinophilic, granular cytoplasm. The cytoplasm stained positively with stains used to demonstrate mitochondria (phosphotungstic acid-hematoxylin, Novelli, Cresylecht violet V, and Kluver-Barrera Luxol fast blue stains). Immunohistochemical reactions demonstrated an epithelial origin (keratin and epithelial membrane antigen), whereas markers for myoepithelial derivation (S-100 protein, actin, and glial fibrillary acidic protein) were not identified. At the time this study was conducted, all patients with submandibular oncocytomas were either alive without evidence of disease or had died without evidence of recurrent disease, with surgical resection the only treatment.
Submandibular gland oncocytomas are rare, benign tumors. The tumor cells are filled with mitochondria, which are easily demonstrated by histochemical reactions. Complete surgical resection is adequate therapy.
嗜酸细胞瘤是涎腺良性肿瘤，约占所有涎腺肿瘤的1.5%。然而，下颌下腺嗜酸细胞瘤确实不常见。
回顾了武装部队病理研究所口腔和耳鼻喉肿瘤登记处档案中的22例下颌下腺嗜酸细胞瘤病例，并对组织学标准、组织化学和免疫组化反应以及超微结构和临床随访数据进行了分析。
患者包括11名女性和11名男性，年龄21 - 88岁，就诊时平均年龄为58.7岁。临床上，肿瘤通常是下颌下腺的无症状肿块，大小在数周至20年的时间内增大，偶尔伴有疼痛（n = 9）。肿瘤最大直径为0.7至7 cm，边界清楚至有包膜。组织学上，肿瘤的特征是具有嗜酸性、颗粒状细胞质的大上皮细胞。细胞质在用用于显示线粒体的染色剂（磷钨酸苏木精、诺维利、甲酚紫V和克卢弗 - 巴雷拉变色酸2R染色剂）染色时呈阳性。免疫组化反应显示为上皮起源（角蛋白和上皮膜抗原），而未发现肌上皮来源的标志物（S - 100蛋白、肌动蛋白和胶质纤维酸性蛋白）。在进行本研究时，所有下颌下嗜酸细胞瘤患者要么存活且无疾病证据，要么死亡且无复发疾病证据，手术切除是唯一的治疗方法。
下颌下腺嗜酸细胞瘤是罕见的良性肿瘤。肿瘤细胞充满线粒体，这可通过组织化学反应轻易显示。完整的手术切除是足够的治疗方法。
