Norman R J, Masters S, Hague W
Reproductive Medicine Unit, University of Adelaide, Queen Elizabeth Hospital, Woodville, Australia.
Fertil Steril. 1996 Dec;66(6):942-7. doi: 10.1016/s0015-0282(16)58687-7.
To determine whether disorders of insulin secretion are common in male and female family members of subjects with polycystic ovary syndrome (PCOS).
Family study of siblings and parents of PCOS subjects (five families). All proband cases met the criteria of polycystic ovaries (PCO) by ultrasound (US) and hyperandrogenism.
University Reproductive Medicine Unit.
PATIENT(S): Family members of PCOS subjects.
INTERVENTION(S): Oral glucose tolerance testing (OGTT), insulin, and lipids were measured. Clinical examination including assessment of premature baldness in men and US of ovaries in female members.
MAIN OUTCOME MEASURE(S): Insulin, lipids, and clinical parameters.
RESULT(S): Hyperinsulinemia (69%) and hypertriglyceridemia (56%) was common in family members as were PCO in 79% of 24 females and premature baldness in men in 88% of eight subjects.
CONCLUSION(S): Hyperinsulinemia is a potential metabolic and genetic marker for subjects who may be carriers of a familial tendency for PCO.
确定胰岛素分泌紊乱在多囊卵巢综合征（PCOS）患者的男性和女性家庭成员中是否常见。
对PCOS患者（五个家庭）的兄弟姐妹和父母进行家系研究。所有先证者病例经超声（US）检查符合多囊卵巢（PCO）标准且存在高雄激素血症。
大学生殖医学科。
PCOS患者的家庭成员。
进行口服葡萄糖耐量试验（OGTT），测量胰岛素和血脂。进行临床检查，包括评估男性的早发性秃发情况以及女性成员的卵巢超声检查。
胰岛素、血脂和临床参数。
高胰岛素血症（69%）和高甘油三酯血症（56%）在家庭成员中很常见，24名女性中有79%存在PCO，8名男性中有88%存在早发性秃发。
高胰岛素血症是可能携带PCO家族倾向的个体的潜在代谢和遗传标志物。
