Bezáková L, Misik V, Máleková L, Svajdlenka E, Kostálová D
Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, J. A. Comenius University, Bratislava, Slovakia.
Pharmazie. 1996 Oct;51(10):758-61.
Products of lipoxygenase metabolism are known to play a role in the pathogenesis of psoriasis. Six bisbenzylisoquinoline (BBIQ) alkaloids, oxyacanthine, armoline, baluchistine, berbamine, obamegine, aquifoline, isolated from Mahonia aquifolium, were tested for lipoxygenase inhibition. Berbamine and oxyacanthine were the most potent lipoxygenase inhibitors, whereas aromoline and baluchistine exhibited only very low potencies. Oxyacanthine and berbamine were also among the most active compounds to inhibit lipid peroxidation. Between the results of lipoxygenase inhibition and the lipid peroxidation a linear correlation was found (r = 0.9533). Our data suggest that in the mechanism of lipoxygenase inhibition by these alkaloids, inhibition of lipid peroxide substrate accumulation, either by direct reaction with peroxide or by scavenging or lipid-derived radicals, may play a role. Inhibition of lipoxygenase by these compounds may contribute to the therapeutic effect of Mahonia aquifolium extracts in treatment of diseases in pathogenesis of which he products of lipoxygenase metabolism are involved.
已知脂氧合酶代谢产物在银屑病的发病机制中起作用。从阔叶十大功劳中分离出的六种双苄基异喹啉（BBIQ）生物碱，即氧化刺桐碱、armoline、巴鲁奇斯汀、小檗胺、奥贝吉宁、水叶碱，进行了脂氧合酶抑制测试。小檗胺和氧化刺桐碱是最有效的脂氧合酶抑制剂，而armoline和巴鲁奇斯汀的效力非常低。氧化刺桐碱和小檗胺也是抑制脂质过氧化最活跃的化合物之一。在脂氧合酶抑制结果和脂质过氧化之间发现了线性相关性（r = 0.9533）。我们的数据表明，在这些生物碱抑制脂氧合酶的机制中，通过与过氧化物直接反应或通过清除脂质衍生的自由基来抑制脂质过氧化物底物积累可能起作用。这些化合物对脂氧合酶的抑制作用可能有助于阔叶十大功劳提取物对脂氧合酶代谢产物参与发病机制的疾病的治疗效果。
