Kostálová D, Bukovský M, Koscová H, Kardosová A
Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Ceska Slov Farm. 2001 Nov;50(6):286-9.
Crude extracts obtained from the stem bark of Mahonia aquifolium have been investigated as to the chemical composition and anticomplementary activity. The results show that their anticomplementary activity is mainly due to the alkaloid components. Especially the BBI alkaloid fraction and berberine showed a strong inhibitory effect on CH50 total hemolytic complement assay. The crude extract of M. aquifolium was less active than berberine or the fraction BBI alkaloids. The results indicate that the fraction of BBI alkaloids and berberine largely account for the immunomodulatory activity of the crude extract of M. aquifolium.
已对从阔叶十大功劳茎皮中获得的粗提物进行了化学成分和抗补体活性研究。结果表明，它们的抗补体活性主要归因于生物碱成分。特别是BBI生物碱组分和小檗碱对CH50总溶血补体测定显示出强烈的抑制作用。阔叶十大功劳粗提物的活性低于小檗碱或BBI生物碱组分。结果表明，BBI生物碱组分和小檗碱在很大程度上解释了阔叶十大功劳粗提物的免疫调节活性。
