Kinawi A, Baumgartl I
J Clin Chem Clin Biochem. 1977 Jun;15(6):345-8.
The effect of cyclamate on the anticoagulant activity of phenprocoumon was investigated in rats after single oral doses of phenprocoumon, cyclamate, or phenprocoumon/cyclamate. By means of high pressure liquid chromatrography [HPLC] the change of the concentration of phenprocoumon per unit time in sera was determined. The anticoagulant acitivity of phenprocoumon was determined by the extension of the prothromin-time (Quick-test). It was found that cyclamate gives rise to an elevated of phenprocoumon in the blood, and a reduction of the anticoagulanting potency.
在大鼠单次口服苯丙香豆素、甜蜜素或苯丙香豆素/甜蜜素后，研究了甜蜜素对苯丙香豆素抗凝活性的影响。通过高压液相色谱法[HPLC]测定血清中苯丙香豆素浓度随时间的变化。苯丙香豆素的抗凝活性通过凝血酶原时间（Quick试验）的延长来测定。结果发现，甜蜜素会导致血液中苯丙香豆素水平升高，抗凝效力降低。
