Partrick D A, Moore F A, Moore E E, Biffl W L, Sauaia A, Barnett C C
Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center, Denver, USA.
Am J Surg. 1996 Nov;172(5):425-9; discussed 429-31. doi: 10.1016/s0002-9610(96)00252-8.
Interleukin-6 (IL-6), interleukin-8 (IL-8), and adhesion molecules have been implicated as mediators in neutrophil (PMN) and endothelial cell (EC) interactions leading to postinjury multiple organ failure (MOF). Our hypothesis was that circulating levels of IL-6, IL-8, and soluble intercellular adhesion molecule-1 (sICAM-1) would discriminate patients at risk for postinjury MOF.
Serial plasma levels of IL-6, IL-8, and sICAM-1 were measured in 27 high-risk trauma patients.
The IL-6 and IL-8 levels were significantly elevated in MOF patients compared with non-MOF patients at 12 and 36 hours postinjury. The IL-6 level was also elevated at 84 and 132 hours, and IL-8 at 84 hours. The sICAM-1 level did not become elevated in MOF patients until 132 hours postinjury.
Interleukin-6 and IL-8 are elevated early after trauma and discriminate patients who will develop MOF. Late elevation of sICAM-1 likely results from PMN cytotoxicity leading to EC injury or inflammation.
白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和黏附分子被认为是导致损伤后多器官功能衰竭（MOF）的中性粒细胞（PMN）与内皮细胞（EC）相互作用的介质。我们的假设是，IL-6、IL-8和可溶性细胞间黏附分子-1（sICAM-1）的循环水平可区分有损伤后MOF风险的患者。
对27例高危创伤患者的IL-6、IL-8和sICAM-1的系列血浆水平进行了测定。
与非MOF患者相比，MOF患者在损伤后12小时和36小时时IL-6和IL-8水平显著升高。IL-6水平在84小时和132小时时也升高，IL-8在84小时时升高。MOF患者的sICAM-1水平直到损伤后132小时才升高。
白细胞介素-6和IL-8在创伤后早期升高，并可区分会发生MOF的患者。sICAM-1的后期升高可能是由于PMN细胞毒性导致EC损伤或炎症所致。
