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肠易激综合征对生活质量的影响。

Impact of irritable bowel syndrome on quality of life.

作者信息

Whitehead W E, Burnett C K, Cook E W, Taub E

机构信息

Division of Digestive Diseases, University of North Carolina at Chapel Hill, USA.

出版信息

Dig Dis Sci. 1996 Nov;41(11):2248-53. doi: 10.1007/BF02071408.

Abstract

The aims of this study were to determine the impact of irritable bowel syndrome on quality of life using a well-standardized measure, the SF-36, and to determine whether apparent impairments may be due to neuroticism. Undergraduate students with irritable bowel syndrome who had consulted a physician (41 females, 42 males), students with irritable bowel who had not consulted a physician (91 females, 74 males), and asymptomatic controls (52 females, 70 males) completed questionnaires on quality of life, neuroticism, and psychological distress. Patients showed greater impairment in quality of life than nonconsulters, who in turn showed greater impairment than controls. Neuroticism and psychological distress were correlated with all quality-of-life measures. However, when neuroticism and psychological distress were statistically partialed out, irritable bowel syndrome still had a significant negative impact. The SF-36 may be a useful outcome measure in treatment studies, but investigators will need to correct for confounding influences of neuroticism.

摘要

本研究的目的是使用标准化程度高的测量工具SF-36来确定肠易激综合征对生活质量的影响,并确定明显的损害是否可能归因于神经质。曾咨询过医生的患有肠易激综合征的本科生(41名女性,42名男性)、未咨询过医生的患有肠易激综合征的学生(91名女性,74名男性)以及无症状对照组(52名女性,70名男性)完成了关于生活质量、神经质和心理困扰的问卷调查。患者在生活质量方面的损害比未咨询过医生的患者更大,而未咨询过医生的患者又比对照组有更大的损害。神经质和心理困扰与所有生活质量指标均相关。然而,当在统计上排除神经质和心理困扰的影响后,肠易激综合征仍然有显著的负面影响。SF-36在治疗研究中可能是一种有用的结果测量工具,但研究人员需要校正神经质的混杂影响。

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