Johnstone S J, Barry R J
Department of Psychology, University of Wollongong, NSW, Australia.
Psychiatry Res. 1996 Oct 16;64(3):179-92. doi: 10.1016/s0165-1781(96)02893-4.
Auditory event-related potentials (ERPs) were recorded from 10 children diagnosed with attention deficit hyperactivity disorder (ADHD) and 10 age-, sex-, and IQ-matched control children. ERPs were recorded from 17 electrodes during an auditory two-tone discrimination ("oddball') paradigm. Subjects were instructed to press a hand-held response button to infrequently presented target tones. ERP components elicited to target and non-target stimuli were analyzed for between-group differences. Results indicated that for the children with ADHD relative to control children, an N2 component to non-target stimuli was larger in the posterior region and smaller in the frontal region. The P3b component to target stimuli was smaller in the posterior region and larger in the frontal region for the ADHD group compared with the control group. The between-group differences in P3b scalp distribution are indicative of a between-group difference in the neural generators of P3b. It is proposed that the ADHD group, relative to controls, utilizes an additional cognitive process when processing task-relevant stimuli. This process is more frontally distributed and may reflect an attentional compensation mechanism in the ADHD group.
对10名被诊断患有注意力缺陷多动障碍（ADHD）的儿童和10名年龄、性别及智商相匹配的对照儿童记录了听觉事件相关电位（ERP）。在听觉双音辨别（“oddball”）范式期间，从17个电极记录ERP。受试者被指示按下手持反应按钮以对不常出现的目标音调做出反应。分析了目标和非目标刺激引发的ERP成分的组间差异。结果表明，与对照儿童相比，患有ADHD的儿童对非目标刺激的N2成分在后部区域更大，而在额叶区域更小。与对照组相比，ADHD组对目标刺激的P3b成分在后部区域更小，而在额叶区域更大。P3b头皮分布的组间差异表明P3b神经发生器存在组间差异。有人提出，与对照组相比，ADHD组在处理与任务相关的刺激时会利用额外的认知过程。这个过程在额叶分布更广泛，可能反映了ADHD组的一种注意力补偿机制。
