可卡因对脑绝对血流量的急性影响。
Acute cocaine effects on absolute cerebral blood flow.
作者信息
Wallace E A, Wisniewski G, Zubal G, vanDyck C H, Pfau S E, Smith E O, Rosen M I, Sullivan M C, Woods S W, Kosten T R
机构信息
Department of Psychiatry, Yale University School of Medicine, Connecticut 06516, USA.
出版信息
Psychopharmacology (Berl). 1996 Nov;128(1):17-20. doi: 10.1007/s002130050104.
Cocaine use has been associated with vasoconstriction and stroke, and several studies have demonstrated that it decreases relative cerebral blood flow (rCBF) in humans. However, rCBF has not been quantitated. We compared 40 mg IV cocaine hydrochloride to placebo effects on absolute rCBF in four cocaine users using 99mTc-HMPAO SPECT with a modified microsphere model for CBF quantitation. Cocaine produced significant decreases in rCBF in all regions studied with a mean decrease of 30% in absolute whole brain blood flow (P = 0.002) which was 3-fold greater than relative blood flow changes.
使用可卡因与血管收缩和中风有关，多项研究表明，它会降低人类的相对脑血流量（rCBF）。然而，rCBF尚未进行定量分析。我们使用99mTc-HMPAO单光子发射计算机断层扫描（SPECT）和用于脑血流量定量的改良微球模型，比较了40毫克静脉注射盐酸可卡因与安慰剂对四名可卡因使用者绝对rCBF的影响。可卡因使所有研究区域的rCBF显著降低，绝对全脑血流量平均降低30%（P = 0.002），这比相对血流变化大3倍。
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