Cozzi P J, Lynch W J, Robson N, Vonthethoff L, Lumley T, Morris D L
Department of Urology, University of New South Wales, St George Hospital, Australia.
Br J Urol. 1996 Oct;78(4):589-95. doi: 10.1046/j.1464-410x.1996.16516.x.
To evaluate the two most common urethral warming catheters currently available for their effectiveness in preventing urethral injury in an animal model and thus during transperineal cryosurgery for the treatment of prostate cancer.
PATIENTS, MATERIALS AND METHODS: The warming efficiency of the variable-diameter thin latex-balloon catheter (Cook, Australia) and the fixed-diameter PVC catheter (Candela, USA) were evaluated in a water-bath. A sheep model was then used for subsequent experiments to further evaluate the better catheter. The technique used for the insertion of the Cook catheter in a series of 33 patients treated with prostate cryosurgery is also described.
In vitro, the Cook catheter was more effective (P < 0.01) than the Candela catheter in preventing localized cooling. In vivo, results in five animals showed that the urethral epithelium was viable in all sections that had been protected by the catheter and focally denuded or necrotic in those sections not protected, with each animal used as its own control (P < 0.01 Fisher's exact test). The 33 patients treated while using the Cook catheter had no subsequent complications.
The urethral warming catheter currently in use for prostatic cryosurgery in Australia is more effective in vitro than its competitor and is effective in preventing urethral injury in vivo.
评估目前市面上两种最常见的尿道加温导管在动物模型中预防尿道损伤的有效性，从而评估其在经会阴冷冻手术治疗前列腺癌过程中的有效性。
患者、材料与方法：在水浴中评估可变直径薄乳胶球囊导管（澳大利亚库克公司）和固定直径聚氯乙烯导管（美国坎德拉公司）的加温效率。随后使用绵羊模型进行后续实验，以进一步评估哪种导管更佳。还描述了在33例接受前列腺冷冻手术的患者中插入库克导管所采用的技术。
在体外，库克导管在防止局部冷却方面比坎德拉导管更有效（P < 0.01）。在体内，五只动物的结果显示，在导管保护的所有部位尿道上皮均存活，而在未受保护的部位则有局灶性剥脱或坏死，每只动物自身作为对照（费舍尔精确检验，P < 0.01）。使用库克导管治疗的33例患者术后无并发症。
目前澳大利亚用于前列腺冷冻手术的尿道加温导管在体外比其竞品更有效，且在体内可有效预防尿道损伤。
